A new sensor toolkit for studying neuropeptides

News Excerpt:

Researchers have developed and characterized a series of highly selective and sensitive GPCR activation-based sensors (GRABs) for detecting several neuropeptides.

About Neuropeptides:

  • Neuropeptides are small chains of amino acids that play vital roles in the endocrine and nervous systems.
  • Neuropeptides are important signaling molecules in the brain that control several vital physiological processes, including metabolism, circadian rhythm, digestion, sleep, and higher-order cognitive activities.
  • This makes neuropeptide signaling, which is mostly controlled by G protein-coupled receptors (GPCRs), an important target for medications treating a variety of illnesses and ailments, including diabetes, obesity, chronic pain, and sleeplessness.
  • There are various neuropeptides:
    • Somatostatin (SST) 
    • Corticotropin-releasing factor (CRF)
    • Cholecystokinin (CCK)
    • Neuropeptide Y (NPY) 
    • Neurotensin (NTS) 
    • Vasoactive intestinal peptide (VIP).