New preclinical model for diarrhoeal diseases
A team of IISc researchers has developed a novel transgenic mouse model harbouring a rare human mutation for studying diarrhoeal diseases — which are the most common gastrointestinal disorder worldwide. Given that preclinical models for diarrhoea are not well established, this mouse model provides the first tool to understand the consequences of chronic diarrhoea on the overall health and functioning of the gut.
- Diarrhoeal diseases are the most common gastrointestinal disorder worldwide.
- Diarrhoea caused by infection is the second leading cause of death in children under five years of age, with more than 5 lakh deaths per annum.
- Although treatments and preventions for acute diarrhoea are widely available, the long-term consequences of recurrent and chronic diarrhoea, prevalent in developing countries such as India, are not well understood, IISc said.
- In a recent study, at the department of molecular reproduction, development and genetics developed a novel transgenic mouse model harbouring a rare human mutation initially described in an extended Norwegian family with a history of congenital diarrhoea.
- The mutation is present in the gene encoding receptor guanylyl cyclase-C (GC-C), the protein receptor for diarrhoea-causing heat-stable enterotoxins secreted by Enterotoxigenic Escherichia coli.